Manuscripts and Presentations
ZYN002 – CBD Gel
H. Heussler, J. Cohen, N. Silove, N. Tich, T. Sebree, and S. Siegel. Transdermal Cannabidiol (CBD) Gel for the Treatment of Fragile X Syndrome (FXS). 57th Annual Meeting of the American College of Neuropsychopharmacology (ACNP). Hollywood, FL. December 9-12, 2018.
Transdermal Cannabidiol (CBD) Gel for the Treatment of Fragile X Syndrome
T. O’Brien, MD, FRACP; S. Berkovic, MD, FRACP; J. French; J. Messenheimer, MD; M. Bonn-Miller, PhD; and D. Gutterman, PharmD. Synthetic Transdermal Cannabidiol for the Treatment of Focal Epilepsy in Adults. American Epilepsy Society Annual Meeting 2018. New Orleans, LA. November 29-Dec. 4, 2018.
Synthetic Transdermal Cannabidiol for the Treatment of Focal Epilepsy in Adults
H. Heussler, MD; J. Cohen, MD; N. Silove, MD; N. Tich, PhD; C. O’Neill; and M. Bonn-Miller, PhD. Transdermal Cannabidiol (CBD) Gel for the Treatment of Fragile X Syndrome (FXS). 16th NFXF (National Fragile X Foundation) International Fragile X Conference. Cincinnati, OH. July 11-14, 2018.
Presentation
Poster
Messenheimer J, MD; O’Brien T MD, FRACP; Berkovic, S, MD, FRACP et al. Transdermal Cannabidiol (CBD) Gel for the Treatment of Focal Epilepsy in Adults. 2018 Annual Meeting of the American Academy of Neurology (AAN), Los Angeles, CA April 21-27, 2018.
Transdermal CBD Gel for Adult Focal Epilepsy
Gonzalez-Cuevas G, et al. Unique treatment potential of cannabidiol for the prevention of relapse to drug use: Preclinical proof of principal. Neuropsychopharmacology DOI: 10.1038/S41386-018-0050-8.
Please see the Springer Nature press release here.
O’Brien T MD, FRACP; Berkovic, S, MD, FRACP; French, J, MD, et al. Synthetic Transdermal Cannabidiol for the Treatment of Focal Epilepsy in Adults. 2017 American Epilepsy Society Annual Meeting, Washington, DC. December 1-5, 2017.
Synthetic Transdermal CBD in Adult Focal Epilepsy
Bonn-Miller M, Gutterman D. A Permeation-Enhanced Synthetic Cannabidiol (CBD) Transdermal Gel for the Treatment of PTSD. Military Health System Research Symposium. Orlando, FL. August 15-18, 2016.
CBD Gel for PTSD
Bonn-Miller M, Sebree T, O’Neill C, Messenheimer J. Neuropsychological Effects of ZYN002 (Synthetic Cannabidiol) Transdermal Gel in Healthy Subjects and Patients with Epilepsy: Phase 1, Randomized, Double-Blind, Placebo-Controlled Studies. American Epilepsy Society Annual Meeting. Houston, TX. December 2-6, 2016.
Neuropsychological Effects of ZYN002
Sebree T, O’Neill C, Messenheimer J, Gutterman D. Safety and Tolerability of ZYN002 (Synthetic Cannabidiol) Transdermal Permeation-Enhanced Gel in Healthy Subjects and Epilepsy Patients: Three Phase 1, Randomized, Double-Blind, Placebo-Controlled Studies. American Epilepsy Society Annual Meeting. Houston, TX. December 2-6, 2016.
ZYN002 Safety and Tolerability
ZYN001 – THC Patch
Banks S, O’Neill C, Sebree T. Pharmacokinetic Evaluation of Subcutaneously Administered ZYN001 in Male Sprague-Dawley Rats. PAINWeek. September 8-12, 2015.
PK Evaluation of ZYN001
Gauvin D, O’Neill C, Patterson DR. Respiratory Evaluation of Subcutaneously Administered ZYN001 in Male Sprague-Dawley Rats. PAINWeek. September 8-12, 2015.
Respiratory Evaluation of ZYN001
Cannabinoids and Delivery Systems
Merrick J, Lane B, Sebree T, Yaksh T, O’Neill C, Banks SL. Identification of psychoactive degradants of cannabidiol in simulated gastric and physiological fluid. Cannabis and Cannabinoid Research 2016;1:1, 102–112, DOI: 10.1089/can.2015.0004.
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Bonn-Miller M, Banks SL, Sebree T. Conversion of Cannabidiol Following Oral Administration: Authors’ Response to Grotenhermen et al. Cannabis and Cannabinoid Research 2017;2:1, 5-7.
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Paudel KS, Hammell DC, et al. Cannabidiol bioavailability after nasal and transdermal application: effect of permeation enhancers. Drug Development and Industrial Pharmacy 2010;36(9):1088–1097.
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Fragile X Syndrome
Jung KM, Sepers M, et al. Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome. Nat Commun 2012;3:1080.
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Qin M, Zeidler Z, et al. Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome. Behav Brain Res 2015 Sep 15;291:164-71.
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Epilepsy
Consroe P, Wolkin A. Cannabidiol–antiepileptic drug comparisons and interactions in experimentally induced seizures in rats. J Pharmacol Exp Ther. 1977 Apr;201(1):26-32.
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Consroe P, Benedito MA, et al. Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice. Eur J Pharmacol. 1982 Sep 24;83(3-4):293-8.
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Cunha JM, Carlini EA, et al. Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients. Pharmacology 1980;21:175-185.
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Devinsky O, Marsh E, et al. Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. Lancet Neurol 2016; 15: 270–78.
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Friedman D and Devinsky O. Cannabinoids in the Treatment of Epilepsy. N Engl J Med 2015; 373:1048-1058.
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Jones NA, Glyn SE, et al. Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures. Seizure. 2012 Jun;21(5):344-52.
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Jones NA, Hill AJ, Smith I, et al. Cannabidiol Display Antiepileptiform and Antiseizure Properties In Vitro and In Vivo. J Pharmac. and Exper. Therap. 2010;332(2):569-577.
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Porter BE, Jacobson C. Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy. Epilepsy & Behavior 2013;29:574–577.
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Arthritis
Blake DR, Robson P, Ho M, Jubb RW, McCabe CS. Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis. Rheumatol. 2006;45:50-52.
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Hammell DC, Zhang LP, et al. Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. Eur J Pain. 2015 Oct 30. doi: 10.1002/ejp.818.
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Pain
Fine PG, Rosenfeld MJ. The Endocannabinoid System, Cannabinoids, and Pain. Rambam Maimonides Med J 2013;4 (4):e0022.
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Skrabek RQ, Galimova L, et al. Nabilone for the Treatment of Pain in Fibromyalgia. J Pain 2008;9(2):164-173.
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Wallace MS, Marcotte TD, et al. Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy. J Pain 2015 Jul;16(7):616-27.
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Wilsey B, Marcott, TD, et al. Low Dose Vaporized Cannabis Significantly Improves Neuropathic Pain. J Pain 2013;14(2):136-148.
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