Manuscripts and Presentations

ZYN002 – CBD Gel

H. Heussler, MD; J. Cohen, MD; N. Silove, MD; N. Tich, PhD; C. O’Neill; and M. Bonn-Miller, PhD. Transdermal Cannabidiol (CBD) Gel for the Treatment of Fragile X Syndrome (FXS). 16th NFXF (National Fragile X Foundation) International Fragile X Conference. Cincinnati, OH. July 11-14, 2018.
Presentation
Poster

Messenheimer J, MD;  O’Brien T MD, FRACP; Berkovic, S, MD, FRACP et al. Transdermal Cannabidiol (CBD) Gel for the Treatment of Focal Epilepsy in Adults. 2018 Annual Meeting of the American Academy of Neurology (AAN), Los Angeles, CA April 21-27, 2018.
Transdermal CBD Gel for Adult Focal Epilepsy

Gonzalez-Cuevas G, et al. Unique treatment potential of cannabidiol for the prevention of relapse to drug use: Preclinical proof of principal. Neuropsychopharmacology DOI: 10.1038/S41386-018-0050-8.
Please see the Springer Nature press release here.

O’Brien T MD, FRACP; Berkovic, S, MD, FRACP; French, J, MD, et al. Synthetic Transdermal Cannabidiol for the Treatment of Focal Epilepsy in Adults. 2017 American Epilepsy Society Annual Meeting, Washington, DC. December 1-5, 2017.
Synthetic Transdermal CBD in Adult Focal Epilepsy

Bonn-Miller M, Gutterman D. A Permeation-Enhanced Synthetic Cannabidiol (CBD) Transdermal Gel for the Treatment of PTSD. Military Health System Research Symposium. Orlando, FL. August 15-18, 2016.
CBD Gel for PTSD

Bonn-Miller M, Sebree T, O’Neill C, Messenheimer J. Neuropsychological Effects of ZYN002 (Synthetic Cannabidiol) Transdermal Gel in Healthy Subjects and Patients with Epilepsy: Phase 1, Randomized, Double-Blind, Placebo-Controlled Studies. American Epilepsy Society Annual Meeting. Houston, TX. December 2-6, 2016.
Neuropsychological Effects of ZYN002

Sebree T, O’Neill C, Messenheimer J, Gutterman D. Safety and Tolerability of ZYN002 (Synthetic Cannabidiol) Transdermal Permeation-Enhanced Gel in Healthy Subjects and Epilepsy Patients: Three Phase 1, Randomized, Double-Blind, Placebo-Controlled Studies. American Epilepsy Society Annual Meeting. Houston, TX. December 2-6, 2016.
ZYN002 Safety and Tolerability

 

ZYN001 – THC Patch 

Banks S, O’Neill C, Sebree T. Pharmacokinetic Evaluation of Subcutaneously Administered ZYN001 in Male Sprague-Dawley Rats. PAINWeek. September 8-12, 2015.
PK Evaluation of ZYN001

Gauvin D, O’Neill C, Patterson DR. Respiratory Evaluation of Subcutaneously Administered ZYN001 in Male Sprague-Dawley Rats. PAINWeek. September 8-12, 2015.
Respiratory Evaluation of ZYN001

Cannabinoids and  Delivery Systems

Merrick J, Lane B, Sebree T, Yaksh T, O’Neill C, Banks SL. Identification of psychoactive degradants of cannabidiol in simulated gastric and physiological fluid. Cannabis and Cannabinoid Research 2016;1:1, 102–112, DOI: 10.1089/can.2015.0004.
Link to Article

Bonn-Miller M, Banks SL,  Sebree T. Conversion of Cannabidiol Following Oral Administration: Authors’ Response to Grotenhermen et al. Cannabis and Cannabinoid Research 2017;2:1, 5-7.
Link to Article

Paudel KS, Hammell DC, et al. Cannabidiol bioavailability after nasal and transdermal application: effect of permeation enhancers. Drug Development and Industrial Pharmacy 2010;36(9):1088–1097.
Link to Article

 

Fragile X Syndrome

Jung KM, Sepers M, et al. Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome. Nat Commun 2012;3:1080.
Link to Article

Qin M, Zeidler Z, et al. Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome. Behav Brain Res 2015 Sep 15;291:164-71.
Link to Article

 

Epilepsy

Consroe P, Wolkin A. Cannabidiol–antiepileptic drug comparisons and interactions in experimentally induced seizures in rats. J Pharmacol Exp Ther. 1977 Apr;201(1):26-32.
Link to Article

Consroe P, Benedito MA, et al. Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice. Eur J Pharmacol. 1982 Sep 24;83(3-4):293-8.
Link to Article

Cunha JM, Carlini EA, et al. Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients. Pharmacology 1980;21:175-185.
Link to Article

Devinsky O, Marsh E, et al. Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. Lancet Neurol 2016; 15: 270–78.
Link to article

Friedman D and Devinsky O. Cannabinoids in the Treatment of Epilepsy. N Engl J Med 2015; 373:1048-1058.
Link to Article

Jones NA, Glyn SE, et al. Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures. Seizure. 2012 Jun;21(5):344-52.
Link to Article

Jones NA, Hill AJ, Smith I, et al. Cannabidiol Display Antiepileptiform and Antiseizure Properties In Vitro and In Vivo. J Pharmac. and Exper. Therap. 2010;332(2):569-577.
Link to Article

Porter BE, Jacobson C. Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy. Epilepsy & Behavior 2013;29:574–577.
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Arthritis

Blake DR, Robson P, Ho M, Jubb RW, McCabe CS. Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis. Rheumatol. 2006;45:50-52.
Link to Article

Hammell DC, Zhang LP, et al. Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. Eur J Pain. 2015 Oct 30. doi: 10.1002/ejp.818.
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Pain

Fine PG, Rosenfeld MJ. The Endocannabinoid System, Cannabinoids, and Pain. Rambam Maimonides Med J 2013;4 (4):e0022.
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Skrabek RQ, Galimova L, et al. Nabilone for the Treatment of Pain in Fibromyalgia. J Pain 2008;9(2):164-173.
Link to Article

Wallace MS, Marcotte TD, et al. Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy. J Pain 2015 Jul;16(7):616-27.
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Wilsey B, Marcott, TD, et al. Low Dose Vaporized Cannabis Significantly Improves Neuropathic Pain. J Pain 2013;14(2):136-148.
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