Manuscripts and Presentations

ZYN002 – CBD Gel

O’Brien T MD, FRACP; Berkovic, S, MD, FRACP; French, J, MD, et al. Synthetic Transdermal Cannabidiol for the Treatment of Focal Epilepsy in Adults. 2017 American Epilepsy Society Annual Meeting, Washington, DC. December 1-5, 2017.
Synthetic Transdermal CBD in Adult Focal Epilepsy

Bonn-Miller M, Gutterman D. A Permeation-Enhanced Synthetic Cannabidiol (CBD) Transdermal Gel for the Treatment of PTSD. Military Health System Research Symposium. Orlando, FL. August 15-18, 2016.
CBD Gel for PTSD

Bonn-Miller M, Sebree T, O’Neill C, Messenheimer J. Neuropsychological Effects of ZYN002 (Synthetic Cannabidiol) Transdermal Gel in Healthy Subjects and Patients with Epilepsy: Phase 1, Randomized, Double-Blind, Placebo-Controlled Studies. American Epilepsy Society Annual Meeting. Houston, TX. December 2-6, 2016.
Neuropsychological Effects of ZYN002

Sebree T, O’Neill C, Messenheimer J, Gutterman D. Safety and Tolerability of ZYN002 (Synthetic Cannabidiol) Transdermal Permeation-Enhanced Gel in Healthy Subjects and Epilepsy Patients: Three Phase 1, Randomized, Double-Blind, Placebo-Controlled Studies. American Epilepsy Society Annual Meeting. Houston, TX. December 2-6, 2016.
ZYN002 Safety and Tolerability

 

ZYN001 – THC Patch 

Banks S, O’Neill C, Sebree T. Pharmacokinetic Evaluation of Subcutaneously Administered ZYN001 in Male Sprague-Dawley Rats. PAINWeek. September 8-12, 2015.
PK Evaluation of ZYN001

Gauvin D, O’Neill C, Patterson DR. Respiratory Evaluation of Subcutaneously Administered ZYN001 in Male Sprague-Dawley Rats. PAINWeek. September 8-12, 2015.
Respiratory Evaluation of ZYN001

Cannabinoids and  Delivery Systems

Merrick J, Lane B, Sebree T, Yaksh T, O’Neill C, Banks SL. Identification of psychoactive degradants of cannabidiol in simulated gastric and physiological fluid. Cannabis and Cannabinoid Research 2016;1:1, 102–112, DOI: 10.1089/can.2015.0004.
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Bonn-Miller M, Banks SL,  Sebree T. Conversion of Cannabidiol Following Oral Administration: Authors’ Response to Grotenhermen et al. Cannabis and Cannabinoid Research 2017;2:1, 5-7.
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Paudel KS, Hammell DC, et al. Cannabidiol bioavailability after nasal and transdermal application: effect of permeation enhancersDrug Development and Industrial Pharmacy 2010;36(9):1088–1097.
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Fragile X Syndrome

Jung KM, Sepers M, et al. Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome. Nat Commun 2012;3:1080.
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Qin M, Zeidler Z, et al. Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome. Behav Brain Res 2015 Sep 15;291:164-71.
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Epilepsy

Consroe P, Wolkin A. Cannabidiol–antiepileptic drug comparisons and interactions in experimentally induced seizures in rats. J Pharmacol Exp Ther. 1977 Apr;201(1):26-32.
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Consroe P, Benedito MA, et al. Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice. Eur J Pharmacol. 1982 Sep 24;83(3-4):293-8.
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Cunha JM, Carlini EA, et al. Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients. Pharmacology 1980;21:175-185.
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Devinsky O, Marsh E, et al. Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. Lancet Neurol 2016; 15: 270–78.
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Friedman D and Devinsky O. Cannabinoids in the Treatment of Epilepsy. N Engl J Med 2015; 373:1048-1058.
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Jones NA, Glyn SE, et al. Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures. Seizure. 2012 Jun;21(5):344-52.
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Jones NA, Hill AJ, Smith I, et al. Cannabidiol Display Antiepileptiform and Antiseizure Properties In Vitro and In Vivo. J Pharmac. and Exper. Therap. 2010;332(2):569-577.
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Porter BE, Jacobson C. Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsyEpilepsy & Behavior 2013;29:574–577.
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Arthritis

Blake DR, Robson P, Ho M, Jubb RW, McCabe CS. Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis. Rheumatol. 2006;45:50-52.
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Hammell DC, Zhang LP, et al. Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. Eur J Pain. 2015 Oct 30. doi: 10.1002/ejp.818.
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Pain

Fine PG, Rosenfeld MJ. The Endocannabinoid System, Cannabinoids, and Pain. Rambam Maimonides Med J 2013;4 (4):e0022.
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Skrabek RQ, Galimova L, et al. Nabilone for the Treatment of Pain in FibromyalgiaJ Pain 2008;9(2):164-173.
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Wallace MS, Marcotte TD, et al. Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy. J Pain 2015 Jul;16(7):616-27.
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Wilsey B, Marcott, TD, et al. Low Dose Vaporized Cannabis Significantly Improves Neuropathic Pain. J Pain 2013;14(2):136-148.
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